For me, it would be GLaDOS.
Portal 2 spoiler
She deleted the one remaining human part of herself because it was just too much to deal with. She releases you at the end of Portal 2 as a path of least resistance measure because “killing you is hard.”
What about you, what is your favorite media villain?
Similarly to Bane in The Dark Knight, the writer was trying to attack a perspective they didn’t actually understand and had to add in a bunch of pointless, self-defeating evil to make the guys fighting for the status quo the good guys.