Not to take away from your post but the trick to riding a bike is not to go slow. The faster you go the easier it is to balance.

Just like walking a tray of glasses, if you slow down (especially abruptly) the change in momentum can topple some, but keep moving and ‘she’ll be right’.

Currently work for an organization helping people on centrelink / workforce benefits get a job.

I’ve managed pubs, nightclubs and restaurants. Been a dishy and wait person.

Managed a warehouse for consumer pc parts, with the same mob I did marketing and procurment dealing with some big international brands and local distributors.

Worked for a government body (think motor registry but broader) assisting people with forms, really just helping them get across the line before they enter the queue.

Climbed towers and installed mobile equipment / antennas replacing the analog mobile network (3g installs). Installed police cameras in back of their vans along with police radio installs with the same rigging mob.

Highest qualification I have is year 12, some certificates for safe work / working at heights and some hospo related tickets. Nothing special, just a string of random jobs.

KeepassDX is great, works most of the time finding fields in Firefox. Can use biometrics to unlock your database if desired too.

Uses the same databases as I use on my laptop / desktop with no issues.

Mouth fedora

Really don’t understand why people are so happy letting llm do everything for them.

I get a kick out of figuring out how things work, be it my car, a podman container running under nixos or flashing a price of hardware to gain further control over it. An understanding of action and concequence really gets skipped entirely.

People from my work happily let llms throw code together without any understanding of the how’s and whys (I work in unrelated areas to programming / coding) and it just baffles me. Even one of my workplaces used a llm to make a Facebook ad, and so clearly it became an internal meme (and probably outside of work).

The Australian government is embracing llms and its baffling my mind as to why, ATO, ServiceNSW and probably another stack all gobble this shit up. Its in their training programs (images, text) and in your face while working. Actually absurd in my eyes.

I had a laptop running as a container machine / image processing for frigate using its iGPU.

Kicked around in my rack without the screen housing, or the bottom housing for a few years. Didn’t have ethernet, so I grabbed a M.2 a+e to Ethernet adaptor which worked a champion.

Until I let it short out on the tray it was resting on, wasn’t expensive and replaced it with a cheap erying ES motherboard.

If you aren’t using the wifi onboard you may be able to remove that M.2 a+e and install a dual sata m.2

Does depend on motherboard but possible.

Don’t worry, M$ say you can launch the command line in 90ms now!

Cant wait to see if Erying get some ES boards on the market from this generation.

My 13th gen Erying ES board is an absolute champion, I’d love to retire my power hungry 9th gen 9900k file / media server with something more capable in the iGPU department.

Yeah I only run 98 (Australia, no ethanol) in my MK6 golf. I’d love to be able to run E85 or E10 but that requires new hoses and an ECU tune. I’d do the hardware myself and have a shop handle the ECU, however time is such a valuable thing these days.

98 around here is approx 2.15 / L or 5.80~ per galon. E85 is similar in price to 98, while E10 is around 1.70.

Nothing also do some. Nothing Ear (Stick)

https://www.notebookcheck.net/Nothing-Ear-Stick-TWS-headphones-review-Transparent-sound.665463.0.html

However I’m not sure if they are currently being produced, they do some open, over ear buds however; they all have the rubbish pinch gestures vs the old touch from the AirPods 1 / 2.

www.bbc.com

Former Chick-fil-A employee charged in $80,000 mac-and-cheese scheme

Harry Sekulich

2 - 3 minutes

Grapevine Police Department/ Facebook CCTV shows a man tapping at a touch-screen register wearing a brown puffer vest, backward baseball cap and blue jeans.Grapevine Police Department/ Facebook

CCTV shows the accused at a touch-screen register where he allegedly rang up hundreds of portions of mac-and-cheese.

Texas police have charged a former Chick-fil-A employee for allegedly defrauding the fast food company of the cost of 800 trays of mac-and-cheese.

The Grapevine Police Department alleges that the employee had been fired a month earlier, but returned to a branch of the fast food chain and made his way behind the counter, where he rang up the catering-sized portions of the rich pasta dish.

They say he then refunded the cost of the order – $80,000 (£58,800) – to his personal credit cards.

Police tried to arrest him multiple times before succeeding on 17 April, the department said in a social media statement. He was charged with property theft, money laundering and evading arrest.

Getty Images Chick-fil-A restaurant logo seen in Houston, Texas.Getty Images

US media named the suspect as 23-year-old Keyshun Jones. Records show he is currently in custody at Green Bay prison in Forth Worth, Texas. The New York Times reported that Jones’s lawyer declined to comment.

The Chick-fil-A catering menu lists the cost of a large tray of its mac-and-cheese at around $100 depending on location. The number of calories in the baked macaroni dish, which features three types of cheese, is almost 10,000 (40,000 kilojoules).

The Chick-fil-A store shared surveillance footage appearing to show the sacked worker returning to the store and using a register behind the service counter.

CCTV footage shows the man wearing a brown puffer vest, blue jeans and backwards white cap, not the chain’s branded red polo uniform.

It is alleged he used the restaurant’s point-of-sale system to issue unauthorised refunds to his personal accounts. It is unclear why he was fired before the incident.

He was eventually found and arrested following a joint operation of the Texas attorney general’s Fugitive Task Force and the Fort Worth Police Department.

The BBC has contacted Chick-fil-A’s media office for comment.

I’ve had my current dishwasher for at least 15 years. Replaced a few grommets for the top spinning arm and its still chugging away like a champion.

The print on the front has been re written in perminant marker (so we know which blinding blue led corresponds to which mode) but honestly couldn’t ask for much more in an appliance.

From memory it was on special for maybe $200. Wife wants to replace it but I don’t have the heart to let it go just yet.

Man what are you paying per kwh? I’m averaging ~$0.21 AUD using a supplier who offers a variable market wholesale price.

I’d thought my rack was a bit of a hog with a z390 9900k and erying es system, but checking my current usage it’s vibing at 180kwh~

At 9:20 pm my rack has set me back $0.80 for the day (excluding misc connection fees and so forth). Most of my daily use would be in heating / cooling with two split systems & the wife WFH.

Yeah I’m stuck between those two options however it’s for much later down the road in my case. House needs a renovation but finances don’t allow just yet.

I have a mix of TP Link wifi globes, IKEA ZigBee and Hue Zigbee throughout the house. Zigbee are controlled by a SLZB 06 and ZHA / MQTT. By far the Hue are the best I’ve tested and have been in service for around 10 years.

You must feel compressed.

I’ve got three of the old Google wifi pucks, all running openwrt. Bit of a mess around to find a working flash drive but no complaints now.

Only wifi 5 but all honesty that’s all we need at home.

You can export them from the Google authenticator app and import into something like keepassdx. Its a bit of a workaround doing such, having to read the data from the QR code but entirely possible.

https://www.keepassdx.com/

Mine sync between devices using Syncthing, merging forked credentials is easy enough to fix too with the desktop app.

Berman et al., Sci. Adv. 12, eaeb3034 (2026) 1 April 2026

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P L A N T S C I E N C E S

Complete biosynthesis of psychedelic tryptamines from

three kingdoms in plants

Paula Berman1,2

*†, Janka Höfer 1

†, Herschel Mehlman1

, Efrat Almekias-Siegl1

, Olga Khersonsky 3

,

Younghui Dong 4

‡, Uwe Heinig4

, Liron Sulimani5

, Let Kho Hao1,2

, Shahar Cohen2

, Yoav Peleg4

,

Sagit Meir1

, Ilana Rogachev 1

, David Meiri5

, Sarel J. Fleishman3

, Asaph Aharoni1

*

Psychedelic indolethylamines with therapeutic potential are naturally produced in plants, fungi, and animals.

Here, we elucidated the complete N,N-dimethyltryptamine (DMT) biosynthetic pathway in hallucinogenic plant

species traditionally used in shamanic rituals for spiritual healing. Leveraging the similarities in their chemical

structures, we reconstructed in one plant assay the full biosynthetic pathways of five renowned natural psyche-

delics; psilocin and psilocybin found in mushrooms, DMT from plants, and bufotenin and 5-methoxy-DMT secret-

ed by the Sonoran Desert toad. We further engineered halogenated analogs of these molecules, which do not

naturally occur in plants and exhibit prospective therapeutic potential for psychiatric conditions. Blending cata-

lytic functions across the tree of life, coupled with metabolic engineering guided by rational protein design of

mutant enzymes, enabled substantially more efficient in planta production of the indolethylamine components.

This work establishes a versatile platform for concurrent biosynthesis and diversification of psychoactive indole-

thylamines, paving the way for their production in plants.

INTRODUCTION

For thousands of years, psychedelic substances have been used by

indigenous cultures as entheogens in rituals intended to induce al-

tered states of consciousness for spiritual and therapeutic purposes.

Psilocybin-containing mushrooms were central to ancient Aztec

ceremonies (1), while N,N-dimethyltryptamine (DMT), the pri-

mary psychoactive component of ayahuasca, has long been used

in traditional Amazonian rituals. This ceremonial brew combines

Psychotria viridis (a natural source of DMT) with Banisteriopsis caapi,

which provides β-carboline monoamine oxidase (MAO) inhibi-

tors that render DMT orally active (1, 2). Similarly, 5-methoxy-N,N-

dimethyltryptamine (5-MeO-DMT), found in the secretion of

the Sonoran Desert toad (Incilius alvarius) and in several plant spe-

cies, is thought to have been used ceremonially by indigenous

groups in northern Mexico (3). 5-MeO-DMT has been described

as the most potent DMT analog, being about 4- to 10-fold more po-

tent than DMT in humans and is known to induce psychedelic ex-

periences that are distinct from those of DMT (4). Knowledge of

the traditional use of these molecules has fueled contemporary

therapeutic interest in psychedelics as treatments for neuropsychiat-

ric conditions.

Recent studies have shown that classical indolethylamine psy-

chedelics promote neuroplasticity and modulate serotonergic cir-

cuits, primarily through 5-HT 2A receptor activation (5–7). These

compounds have demonstrated therapeutic potential for depression,

anxiety, posttraumatic stress disorder, and addiction (5–8), with psi-

locybin receiving Food and Drug Administration Breakthrough

Therapy designation for major depressive disorder in 2019 (6, 7).

Although widely considered hallucinogenic, psilocybin itself func-

tions as a prodrug, undergoing enzymatic dephosphorylation in the

digestive tract and liver to produce psilocin, the active compound

responsible for its psychoactive effects. DMT is produced by a broad

range of plant species and, in low abundance, by certain animals (2).

When administered via smoking or intravenous injection, it pro-

duces rapid and intense psychoactive effects that typically peak with-

in 5 min and subside within 30 min, due to rapid metabolism by

MAO enzymes in the liver. Coadministration with MAO inhibitors

can extend the half-life of DMT in vivo (2). The traditional use of

ayahuasca exemplifies how combining compounds from different

sources can enable oral activity; however, such combinations require

carefully balanced dosing to mitigate adverse effects associated with

MAO inhibition (9).

The expanding clinical interest in psychedelics as therapeutics

has sparked the need for scalable and versatile production platforms

and structural diversification (10, 11). Traditionally, the supply of

psychedelics relies on natural producers, mainly plants, fungi, and

the Sonoran Desert toad. Harvesting these organisms for their psy-

choactive compounds raises ecological and ethical concerns, being

increasingly threatened by habitat loss and overexploitation (12).

While synthetic routes for these compounds are available and, in

some cases, relatively straightforward, they still require compound-

specific reactants, can lead to unwanted intermediates and prod-

ucts, and require several processing steps (2, 13, 14). Biocatalys

My yard was infested with bur clover, horrible stuff when you have pets. Worse when your pets are poodle mixes.

Other clover yeah they chill.